Oxycodone Hydrochloride Oral Solution + Phenytoin Interaction
Majorinteraction on record
Description
CYP3A4 inducer that decreases oxycodone plasma concentration, resulting in decreased efficacy or withdrawal syndrome. Upon discontinuation, increased oxycodone levels may cause serious respiratory depression.
Mechanism
CYP3A4 induction
Source: NLP:oxycodone hydrochloride oral solution