Oxycodone Hydrochloride And Acetaminophen + Rifampin Interaction

Majorinteraction on record

Description

CYP3A4 inducer that decreases oxycodone plasma concentration, resulting in decreased efficacy and withdrawal syndrome risk. Stopping rifampin increases oxycodone levels and serious respiratory depression risk.

Mechanism

CYP3A4 induction

Source: NLP:oxycodone hydrochloride and acetaminophen