Oxycodone Hydrochloride And Acetaminophen + Phenytoin Interaction
Majorinteraction on record
Description
CYP3A4 inducer that decreases oxycodone plasma concentration, resulting in decreased efficacy and withdrawal syndrome risk. Stopping phenytoin increases oxycodone levels and serious respiratory depression risk.
Mechanism
CYP3A4 induction
Source: NLP:oxycodone hydrochloride and acetaminophen