Oral Contraceptives + Bosentan Interaction
Majorinteraction on record
Description
Bosentan reduces effectiveness of oral, injectable, transdermal, and implantable hormonal contraceptives by decreasing exposure to ethinyl estradiol (31% average, up to 66%) and norethindrone (14% average, up to 56%).
Mechanism
CYP3A and CYP2C9 induction by bosentan increases metabolism of contraceptive hormones
Source: NLP:bosentan