Omeprazole Magnesium + Methotrexate Interaction

Majorinteraction on record

Description

Concomitant use, especially at high dose, may elevate and prolong serum concentrations of methotrexate and hydroxymethotrexate, possibly leading to methotrexate toxicities.

Mechanism

Increased serum concentrations and prolonged exposure

Source: NLP:omeprazole magnesium