Omeprazole And Sodium Bicarbonate + Methotrexate Interaction
Majorinteraction on record
Description
Concomitant use may elevate and prolong serum concentrations of methotrexate and metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities.
Mechanism
Elevated and prolonged serum concentrations
Source: NLP:omeprazole sodium bicarbonate