Olmesartan Medoxomil Amlodipine Besylate Hydrochlorothiazide + Simvastatin Interaction

Moderateinteraction on record

Description

Limit simvastatin to 20 mg daily when coadministered with amlodipine.

Mechanism

Amlodipine inhibits CYP3A4 metabolism of simvastatin, increasing its exposure

Source: NLP:olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide