Nsaids + Olmesartan Medoxomil Amlodipine Besylate Hydrochlorothiazide Interaction
Majorinteraction on record
Description
May lead to increased risk of renal impairment, loss of antihypertensive effect, and deterioration of renal function including possible acute renal failure.
Mechanism
NSAIDs inhibit renal prostaglandin synthesis, impairing renal perfusion and reducing antihypertensive efficacy of angiotensin II receptor antagonists.
Source: NLP:olmesartan medoxomil / amlodipine besylate / hydrochlorothiazide