Nortriptyline Hydrochloride + Fluoxetine Interaction

Majorinteraction on record

Description

Inhibits P450 2D6 and may increase nortriptyline plasma concentrations. At least 5 weeks must elapse after fluoxetine withdrawal before initiating nortriptyline due to long half-life.

Mechanism

Inhibition of cytochrome P450 2D6

Source: NLP:nortriptyline hydrochloride