Nilutamide + Theophylline Interaction
Majorinteraction on record
Description
Nilutamide inhibits cytochrome P-450 isoenzymes, reducing metabolism of theophylline and increasing serum half-life, potentially leading to toxic levels. Dosage may need modification.
Mechanism
Inhibition of hepatic cytochrome P-450 isoenzymes reducing drug metabolism
Source: NLP:nilutamide