Naloxone Hydrochloride + Buprenorphine Interaction
Majorinteraction on record
Description
Large doses of naloxone required to antagonize buprenorphine due to its long duration of action and slow dissociation from opioid receptor. Antagonism characterized by gradual onset and decreased duration of effect.
Mechanism
Buprenorphine's slow binding and dissociation from opioid receptor
Source: NLP:naloxone hydrochloride