Monoamine Oxidase Inhibitors Maois + Naltrexone Hydrochloride And Bupropion Hydrochloride Interaction

Contraindicatedinteraction on record

Description

Concomitant use is contraindicated. Bupropion inhibits re-uptake of dopamine and norepinephrine, increasing risk of hypertensive reactions with MAOIs. At least 14 days must elapse between discontinuation of MAOI and initiation of CONTRAVE, and vice versa.

Mechanism

Inhibition of dopamine and norepinephrine re-uptake by bupropion combined with MAOI effects increases hypertensive reaction risk

Source: NLP:naltrexone hydrochloride and bupropion hydrochloride