Monoamine Oxidase Inhibitors (Maois) + Promethazine Hydrochloride And Dextromethorphan Hydrobromide Interaction
Contraindicatedinteraction on record
Description
Hyperpyrexia, hypotension, and death reported with co-administration. Increased extrapyramidal effects when MAO inhibitors used with phenothiazines. Concomitant administration should be avoided.
Mechanism
MAO inhibitors interact with dextromethorphan and phenothiazine component
Source: NLP:promethazine hydrochloride and dextromethorphan hydrobromide