Midazolam Hydrochloride + Cimetidine Interaction
Moderateinteraction on record
Description
Inhibits P450-3A4 enzyme system, decreasing plasma clearance of midazolam and resulting in prolonged sedation. Increased steady-state concentration from 57 to 71 ng/mL.
Mechanism
CYP3A4 inhibition
Source: NLP:midazolam hydrochloride