Methotrexate + Lansoprazole Amoxicillin Clarithromycin Interaction
Majorinteraction on record
Description
Concomitant use may elevate and prolong serum concentrations of methotrexate and its metabolite, potentially leading to methotrexate toxicities.
Mechanism
PPI impairs methotrexate elimination
Source: NLP:lansoprazole, amoxicillin, clarithromycin