Methotrexate + Dexlansoprazole Interaction

Majorinteraction on record

Description

Concomitant use may elevate and prolong serum concentrations of methotrexate and hydroxymethotrexate, possibly leading to toxicities, particularly at high doses.

Mechanism

Reduced renal clearance of methotrexate

Source: NLP:dexlansoprazole