Methadone Hydrochloride + Sertraline Interaction
Majorinteraction on record
Description
SSRI and CYP2D6 inhibitor that increases methadone plasma concentration, resulting in increased opioid effects and risk of fatal overdose.
Mechanism
Inhibition of CYP2D6-mediated methadone N-demethylation
Source: NLP:methadone hydrochloride