Metformin Hydrochloride + Cimetidine Interaction
Majorinteraction on record
Description
OCT2/MATE inhibitor that reduces metformin clearance and may increase risk of lactic acidosis through increased systemic metformin exposure.
Mechanism
Inhibits organic cationic transporter-2 (OCT2) and multidrug and toxin extrusion (MATE)
Source: NLP:metformin hydrochloride