Mercaptopurine + Febuxostat Interaction
Contraindicatedinteraction on record
Description
Febuxostat is contraindicated in patients being treated with mercaptopurine. Concomitant administration could increase plasma concentrations resulting in severe toxicity.
Mechanism
Febuxostat inhibits xanthine oxidase, which metabolizes mercaptopurine
Source: NLP:febuxostat