Mepivacaine Hydrochloride + Epinephrine Interaction

Majorinteraction on record

Description

Local anesthetic solutions containing Epinephrine may produce severe, prolonged hypertension in patients receiving tricyclic antidepressants or monoamine oxidase inhibitors; serious cardiac arrhythmias may occur with potent inhalation anesthetics.

Mechanism

Vasopressor effect potentiation; interaction with inhalation anesthetics

Source: NLP:mepivacaine hydrochloride