Meperidine Hydrochloride + Monoamine Oxidase Inhibitors Maois Interaction
Contraindicatedinteraction on record
Description
Meperidine is contraindicated with MAOIs or within 14 days of stopping them. Can cause unpredictable, severe, and occasionally fatal reactions including serotonin syndrome, respiratory depression, coma, and hypertensive crisis.
Mechanism
Unclear mechanism, possibly related to preexisting hyperphenylalaninemia
Source: NLP:meperidine hydrochloride