Meperidine Hydrochloride + Mao Inhibitors Interaction

Moderateinteraction on record

Description

Concomitant use increases meperidine plasma concentration, resulting in increased or prolonged opioid effects and respiratory depression risk. Dosage reduction may be necessary.

Mechanism

Inhibition of CYP3A4-mediated meperidine metabolism

Source: NLP:meperidine hydrochloride