Mao Inhibitors + Tramadol Hydrochloride Interaction
Majorinteraction on record
Description
Increase tramadol plasma concentration and may increase M1 levels via CYP2D6, risking seizures, serotonin syndrome, opioid toxicity, and potentially fatal respiratory depression.
Mechanism
CYP3A4 inhibition increases tramadol exposure and metabolism via CYP2D6
Source: NLP:tramadol hydrochloride