Mao Inhibitors + Amphetamine Interaction

Contraindicatedinteraction on record

Description

MAOI antidepressants slow amphetamine metabolism, increasing effects on norepinephrine release causing hypertensive crisis. Toxic neurological effects and malignant hyperpyrexia can occur with fatal results.

Mechanism

Decreased amphetamine metabolism via MAO inhibition, increased monoamine release

Source: NLP:amphetamine