Mao Inhibitors + Aliskiren Hemifumarate Interaction
Contraindicatedinteraction on record
Description
Concomitant use with ACE inhibitors in diabetic patients is contraindicated. In non-diabetics, generally avoid combined use, especially with CrCl <60 mL/min, due to increased risk of hypotension, hyperkalemia, and acute renal failure.
Mechanism
Dual blockade of the renin-angiotensin-aldosterone system (RAAS)
Source: NLP:aliskiren hemifumarate