Magnesium Sulfate Heptahydrate + Propofol Interaction

Majorinteraction on record

Description

Potentiation and prolongation of analgesia and CNS depression is possible. Monitor depth of CNS depression frequently and adjust dosage accordingly.

Mechanism

Antagonism of N-methyl-D-aspartate (NMDA) by magnesium sulfate

Source: NLP:magnesium sulfate heptahydrate