Lumacaftor And Ivacaftor + Rifampin Interaction

Majorinteraction on record

Description

Strong CYP3A inducer decreases ivacaftor exposure by 57%, reducing ORKAMBI effectiveness. Co-administration not recommended.

Mechanism

CYP3A induction decreases ivacaftor exposure

Source: NLP:lumacaftor and ivacaftor

Related drug profiles

All Lumacaftor And Ivacaftor interactions →All Rifampin interactions →
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