Lubiprostone + Methadone Interaction
Moderateinteraction on record
Description
Methadone may dose-dependently reduce lubiprostone activation of ClC-2 in the gastrointestinal tract, potentially decreasing lubiprostone efficacy for opioid-induced constipation.
Mechanism
Dose-dependent reduction of ClC-2 activation by lubiprostone in the gastrointestinal tract
Source: NLP:lubiprostone