Losartan Potassium And Hydrochlorothiazide + Mao Inhibitors Interaction
Majorinteraction on record
Description
Risk of deterioration of renal function including possible acute renal failure, and reduced diuretic and antihypertensive effects. Monitor renal function periodically.
Mechanism
COX-2 inhibitors reduce antihypertensive effect and may impair renal function in elderly, volume-depleted, or renally compromised patients
Source: NLP:losartan potassium and hydrochlorothiazide