Lonafarnib + Mao Inhibitors Interaction
Contraindicatedinteraction on record
Description
Concomitant use with strong CYP3A inhibitors is contraindicated. May increase lonafarnib AUC and Cmax, increasing incidence and severity of adverse reactions including QTc interval prolongation.
Mechanism
CYP3A inhibition increases lonafarnib exposure
Source: NLP:lonafarnib