Linagliptin And Metformin Hydrochloride + Topiramate Interaction
Majorinteraction on record
Description
Carbonic anhydrase inhibitors like topiramate decrease serum bicarbonate and induce metabolic acidosis, increasing risk of lactic acidosis when combined with linagliptin and metformin.
Mechanism
Decreases serum bicarbonate and induces non-anion gap, hyperchloremic metabolic acidosis
Source: NLP:linagliptin and metformin hydrochloride