Linagliptin And Metformin Hydrochloride + Ranolazine Interaction
Majorinteraction on record
Description
OCT2/MATE inhibitor that reduces metformin clearance, increasing systemic exposure and risk of lactic acidosis.
Mechanism
Inhibits organic cationic transporter-2 (OCT2) and multidrug and toxin extrusion (MATE) transporters involved in renal elimination of metformin
Source: NLP:linagliptin and metformin hydrochloride