Leflunomide + Rifampin Interaction

Moderateinteraction on record

Description

Rifampin increases plasma concentration of teriflunomide (leflunomide's active metabolite) by 40%. Caution recommended due to potential for continued concentration increases with multiple dosing.

Mechanism

Rifampin is a potent inducer of CYP450 enzymes and transporters

Source: NLP:leflunomide