Ledipasvir And Sofosbuvir + Rifampin Interaction
Majorinteraction on record
Description
P-gp inducer that may decrease ledipasvir and sofosbuvir plasma concentrations, leading to reduced therapeutic effect. Use is not recommended.
Mechanism
P-gp induction decreases ledipasvir and sofosbuvir concentrations
Source: NLP:ledipasvir and sofosbuvir