Lansoprazole + Methotrexate Interaction
Majorinteraction on record
Description
Concomitant use with lansoprazole may elevate and prolong serum concentrations of methotrexate and its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities.
Mechanism
Elevated and prolonged serum concentrations of methotrexate and hydroxymethotrexate
Source: NLP:lansoprazole