Lamotrigine Chewable Dispersible + Dofetilide Interaction
Majorinteraction on record
Description
Coadministration of lamotrigine with dofetilide (OCT2 substrate with narrow therapeutic index) is not recommended.
Mechanism
Lamotrigine inhibits renal tubular secretion via OCT2, increasing dofetilide plasma levels
Source: NLP:lamotrigine chewable dispersible