Lamotrigine + Dofetilide Interaction
Contraindicatedinteraction on record
Description
Coadministration of lamotrigine with dofetilide (OCT2 substrate with narrow therapeutic index) is not recommended due to increased plasma levels.
Mechanism
Lamotrigine inhibits renal tubular secretion via organic cationic transporter 2 (OCT2) proteins
Source: NLP:lamotrigine