Ketoprofen + Methotrexate Interaction
Majorinteraction on record
Description
Ketoprofen may alter methotrexate elimination leading to elevated serum levels and increased toxicity. NSAIDs may competitively inhibit methotrexate accumulation.
Mechanism
Competitive inhibition of methotrexate accumulation; inhibition of renal prostaglandin synthesis
Source: NLP:ketoprofen