Ivabradine + Diltiazem Hydrochloride Interaction
Contraindicatedinteraction on record
Description
Concurrent use increases ivabradine exposure and may exacerbate bradycardia and conduction disturbances. Avoid concomitant use.
Mechanism
CYP450 3A4 inhibition by diltiazem increases ivabradine exposure
Source: NLP:diltiazem hydrochloride