Irinotecan Hydrochloride + Fluorouracil Interaction

Moderateinteraction on record

Description

Co-administration reduces SN-38 Cmax by 14% and AUC by 8%. This sequence is used in combination trials and is recommended.

Mechanism

Reduced active metabolite exposure when irinotecan followed by 5-FU and leucovorin

Source: NLP:irinotecan hydrochloride

Related drug profiles

All Irinotecan Hydrochloride interactions →All Fluorouracil interactions →
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