Imipramine Hydrochloride + Fluoxetine Interaction
Majorinteraction on record
Description
SSRI inhibitor of P450 2D6 that increases imipramine plasma concentration. At least 5 weeks must elapse when switching from fluoxetine to imipramine due to long half-life. Monitoring of TCA plasma levels recommended.
Mechanism
Inhibition of cytochrome P450 2D6
Source: NLP:imipramine hydrochloride