Ibuprofen Oral + Methotrexate Interaction

Majorinteraction on record

Description

NSAIDs may competitively inhibit methotrexate accumulation and enhance methotrexate toxicity. Use with caution when administering concomitantly.

Mechanism

Competitive inhibition of methotrexate accumulation

Source: NLP:ibuprofen oral

Related drug profiles

All Ibuprofen Oral interactions →All Methotrexate interactions →
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