Ibuprofen + Methotrexate Interaction

Majorinteraction on record

Description

NSAIDs competitively inhibit methotrexate accumulation and may enhance methotrexate toxicity. Caution should be used when administered concomitantly.

Mechanism

Competitive inhibition of methotrexate accumulation

Source: NLP:ibuprofen

Related drug profiles

All Ibuprofen interactions →All Methotrexate interactions →
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