Hydrocodone Bitartrate And Ibuprofen + Rifampin Interaction
Majorinteraction on record
Description
CYP3A4 inducer that decreases hydrocodone plasma concentration, resulting in decreased opioid efficacy or withdrawal syndrome. Discontinuation may cause serious respiratory depression.
Mechanism
CYP3A4 induction
Source: NLP:hydrocodone bitartrate and ibuprofen