Guanfacine + Rifampin Interaction
Majorinteraction on record
Description
CYP3A4 inducer that significantly decreases guanfacine plasma concentrations and exposure. Guanfacine dose increase up to double the target dosage may be needed.
Mechanism
Induction of CYP3A4-mediated metabolism of guanfacine
Source: NLP:guanfacine