Grapefruit Juice + Butalbital%2C Acetaminophen%2C Caffeine And Codeine Phosphate Interaction
Majorinteraction on record
Description
CYP3A4 inhibitor may increase codeine plasma concentrations and morphine levels, potentially causing fatal respiratory depression, particularly when added after stable dosing.
Mechanism
Inhibition of CYP3A4, increasing codeine metabolism to morphine via CYP2D6
Source: NLP:butalbital, acetaminophen, caffeine and codeine phosphate