Gemfibrozil + Pioglitazone And Glimepiride Interaction

Majorinteraction on record

Description

Strong CYP2C8 inhibitor significantly increases pioglitazone exposure and half-life. Maximum pioglitazone dose must be limited to 15 mg daily.

Mechanism

CYP2C8 inhibition increases pioglitazone AUC and half-life

Source: NLP:pioglitazone and glimepiride