Gemfibrozil + Pioglitazole And Metformin Hydrochloride Interaction
Majorinteraction on record
Description
Strong CYP2C8 inhibitor significantly increases pioglitazone exposure and half-life, requiring dose reduction to maximum 15 mg pioglitazone and 850 mg metformin daily.
Mechanism
CYP2C8 inhibition
Source: NLP:pioglitazone hydrochloride and metformin hydrochloride