Fluoxetine + Amoxapine Interaction

Moderateinteraction on record

Description

Fluoxetine inhibits P450 2D6; caution is indicated in co-administration with tricyclic antidepressants. At least 5 weeks must elapse before initiating TCA treatment after fluoxetine withdrawal due to long half-life.

Mechanism

Inhibition of cytochrome P450 2D6

Source: NLP:amoxapine