Fentanyl Transdermal + Carbamazepine Interaction
Majorinteraction on record
Description
CYP3A4 inducer; concomitant use can decrease plasma concentration of fentanyl, resulting in decreased efficacy or withdrawal syndrome. Stopping inducer may increase fentanyl levels causing serious respiratory depression.
Mechanism
CYP3A4 induction
Source: NLP:fentanyl transdermal